Сегодня: 14.04.2024
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Последнее обновление: 01.03.2024
Неинвазивный скрининг злокачественных новообразований полости рта <i>in vivo</i> с применением метода лазерно-индуцированной флюоресценции

Неинвазивный скрининг злокачественных новообразований полости рта in vivo с применением метода лазерно-индуцированной флюоресценции

Patil A., Unnikrishnan V.K., Ongole R., Pai K.M., Kartha V.B., Chidangil S.
Ключевые слова: лазерно-индуцированная флюоресценция; скриниг новообразований полости рта; рак полости рта.
2018, том 10, номер 1, стр. 15.

Полный текст статьи

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В ходе исследования у 380 добровольцев зарегистрировано in vivo около 4000 спектров флюоресценции с участков ротовой полости в нормальном (n=133), потенциально злокачественном (n=155) и злокачественном (n=92) состоянии при возбуждении непрерывным волоконным He-Cd лазерой с длиной волны 325 нм. Анализ показал, что суммарные спектры из 7–8 полос возникают в различных видах молекул. В здоровом состоянии (у лиц без патологий полости рта, в том числе связанных с потреблением табачных изделий) слизистые оболочки щек, нижней губы и нижней поверхности языка имеют очень похожие спектры, в то время как спинка языка, его боковая поверхность и небо дают отличные от них и друг от друга спектры. При потенциально злокачественных и злокачественных заболеваниях спектры заметно отличаются на различных участках при различных состояниях. В связи с этим при оптической диагностике целесообразно использовать отдельные эталонные наборы данных о нормальных, потенциально злокачественных или злокачественных состояниях для различных участков.

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Patil A., Unnikrishnan V.K., Ongole R., Pai K.M., Kartha V.B., Chidangil S. Non-Invasive in vivo Screening of Oral Malignancy Using Laser-Induced Fluorescence Based System. Sovremennye tehnologii v medicine 2018; 10(1): 15, https://doi.org/10.17691/stm2018.10.1.02


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