Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review)

Development and introduction of new biotechnological analogs (equivalents) of tissues and organs into clinical practice, such as human skin equivalents (SE), designed for temporal or permanent replacement of damaged or destroyed tissue, remains an urgent problem of regenerative medicine. Currently, full-thickness SE as well as separate skin layers, which include living cells of different types, are being created and investigated.

In our review, we present a comparative analysis of existing SE, both commercial and those being at the stage of preclinical study, analyze their structure and feasibility of application for solving experimental and clinical tasks. Characteristics of the three main variants of SE have also been considered. Examples of stem cell application for creation of SE have been given. The main advantages of using stem cells as a cell component of SE have been described.

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Meleshina A.V., Bystrova A.S., Rogovaya O.S., Vorotelyak E.A., Vasiliev A.V., Zagaynova E.V. Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review). Sovremennye tehnologii v medicine 2017; 9(1): 198, https://doi.org/10.17691/stm2017.9.1.24