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Скаффолды на основе поли-3-оксибутирата и его сополимеров для инженерии костной ткани (обзор)

Скаффолды на основе поли-3-оксибутирата и его сополимеров для инженерии костной ткани (обзор)

А.П. Бонарцев, В.В. Воинова, А.В. Волков, А.А. Мураев, Е.М. Бойко, А.А. Венедиктов, Н.Н. Диденко, А.А. Долгалев
Ключевые слова: скаффолды; матриксы; полиоксиалканоаты; поли-3-оксибутират; мезенхимальные стволовые клетки; костные дефекты; остеоиндуктивные свойства; регенерация костной ткани.
2022, том 14, номер 5, стр. 78.

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Биоразлагаемые и биосовместимые полимеры активно используют в тканевой инженерии для изготовления скаффолдов. Био­медицинские свойства полимерных скаффолдов зависят от физико-химических особенностей и кинетики биодеградации полимерного материала, 3D-микроструктуры и топографии поверхности скаффолдов, наличия минеральных веществ, лекарственных агентов и ростовых факторов, загруженных в скаффолд. Однако помимо этого может проявляться и собственная биологическая активность полимера и продуктов его биодеградации. В обзоре рассмотрены исследования, в которых показано, что скаффолды из поли-3-оксибутирата (ПОБ) и его сополимеров обладают собственной биологической активностью, а именно остеоиндуктивными свойствами. ПОБ способен индуцировать дифференцировку мезенхимальных стволовых клеток в остеогенном направлении in vitro и стимулирует регенерацию костной ткани при моделировании критических и некритических костных дефектов in vivo.

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